CJC-1295 + Ipamorelin: The Most-Studied GH Stack

The blend logic

Somatotropic axis has two hypothalamic signals: GHRH (releases GH) and ghrelin/GHS-R1a (amplifies). Simultaneous activation yields >2× GH release vs sum of each — synergy.

CJC-1295 (no DAC)

Modified GHRH(1-29) — DPP-4 resistant. Half-life ~30 min — produces acute GH pulse. "With DAC" version binds albumin, extends to ~6 days (continuous elevation).

Ipamorelin

Selective GHS-R1a pentapeptide agonist. Key: does not elevate cortisol, prolactin, or hunger. ~2 hour half-life.

The 5+5 mg blend

Vial: 5 mg CJC-1295 + 5 mg Ipamorelin lyophilized together. 10 mg total + 1 mL BAC = 10 mg/mL total = 5 mg/mL of each. 100 mcg + 100 mcg dose = 0.02 mL = 2 units U100.

Nocturnal timing

Natural GH release is nocturnal. Most programs administer 30 min before sleep to align with the physiological pulse.

vs Recombinant HGH

Sermorelin/Tesamorelin/DAC variants

• Sermorelin: native GHRH(1-29), gentle.
• CJC no DAC: optimized, ~30 min half-life.
• CJC with DAC: ~6 days, continuous elevation.
• Tesamorelin: FDA-approved GHRH for visceral fat research.