CJC-1295 + Ipamorelin: The Most-Studied GH Stack
GHRH + ghrelin secretagogue. Why this combination produces an endogenous GH pulse superior to either alone — and how to dose the pre-mixed blend.
The blend logic
Somatotropic axis has two hypothalamic signals: GHRH (releases GH) and ghrelin/GHS-R1a (amplifies). Simultaneous activation yields >2× GH release vs sum of each — synergy.
CJC-1295 (no DAC)
Modified GHRH(1-29) — DPP-4 resistant. Half-life ~30 min — produces acute GH pulse. "With DAC" version binds albumin, extends to ~6 days (continuous elevation).
Ipamorelin
Selective GHS-R1a pentapeptide agonist. Key: does not elevate cortisol, prolactin, or hunger. ~2 hour half-life.
The 5+5 mg blend
Vial: 5 mg CJC-1295 + 5 mg Ipamorelin lyophilized together. 10 mg total + 1 mL BAC = 10 mg/mL total = 5 mg/mL of each. 100 mcg + 100 mcg dose = 0.02 mL = 2 units U100.
Nocturnal timing
Natural GH release is nocturnal. Most programs administer 30 min before sleep to align with the physiological pulse.
vs Recombinant HGH
| Variable | CJC/Ipa blend | HGH recombinant |
|---|---|---|
| Mechanism | Stimulates endogenous | Direct exogenous |
| GH pattern | Pulsatile | Continuous |
| HPA feedback | Preserved | Suppresses axis |
| Monthly cost | ~$170 | ~$300+ |
Sermorelin/Tesamorelin/DAC variants
- Sermorelin: native GHRH(1-29), gentle.
- CJC no DAC: optimized, ~30 min half-life.
- CJC with DAC: ~6 days, continuous elevation.
- Tesamorelin: FDA-approved GHRH for visceral fat research.
Related products
Bakri: GH secretagogues release your own GH in a pulsatile way (more physiological than a non-pulsatile MK-677 ‘dump’). GH/IGF-1 are pro-growth — theoretical tumor caution; Huberman stopped an analog when his PSA rose.
Educational context (RUO). Based on “Peptides: The Science, Uses & Safety” (Huberman Lab, Jun 2026). Not an endorsement by Dr. Bakri or Dr. Huberman. Watch the episode⚠ Research use only. Not medical advice.