Renova Guides
Knowledge base for peptide research. Mechanisms, published studies, reconstitution, stacks — curated by our team.
World Peptide Congress 2026: The Science Behind Renova
We follow the world's leading peptide educators and researchers — the SSRP Institute. The congress's core ideas, in a research frame, linked to our guides.
Read guide →Retatrutide in Phase 3: What TRIUMPH-2 Showed at EASD 2026
The full results of the TRIUMPH-2 trial in obesity and type 2 diabetes: the figures, why there are two numbers for the same result, safety, and what is still missing for an approval.
Read guide →Black-Market Retatrutide: The Study That Measured the Gap With the Trials
An August 2026 preprint: users sourcing from unverified channels report less than half the weight loss seen in trials at 12 months. Why the source matters and how research material gets verified.
Read guide →GLP-1s in the DR: Listed, but Still Not Covered by Insurers
More than a year on the essential medicines list and the ARS still do not cover them. What the Diabetes Observatory said, what the CNSS must authorize, and what it means for access in the DR.
Read guide →Are peptides legal in the Dominican Republic?
Law 42-01, DIGEMAPS and what RUO means. The full framework, the 2026 FDA context and a checklist to evaluate any supplier.
Read guide →Cost per mg of peptides in the DR: comparison table
The full catalog in US$/mg, kept current, with methodology in plain sight, volume discounts and what to verify before comparing suppliers.
Read guide →Peptide Stacking: Synergy, Sequencing, and Combinations
Regenerative medicine is graduating from the single-site injection — but most stacking is still sequential, not combined. How to combine well, and the most-studied combinations.
Read guide →MOTS-c: The Mitochondrial Peptide Explained
Encoded in mitochondrial DNA, MOTS-c regulates metabolism, insulin sensitivity, and exercise response. Why it's become one of the most studied compounds in metabolic longevity research.
Read guide →NAD+: The Coenzyme of Cellular Energy and Longevity
The redox coenzyme that drops ~50% by midlife. Mitochondrial energy, DNA repair, sirtuins, and why it's central to longevity research.
Read guide →Glutathione: The Body's Master Antioxidant
The most abundant intracellular antioxidant tripeptide. GSH/GSSG redox cycle, hepatic detoxification, and why the injectable route is studied.
Read guide →SS-31 (Elamipretide): The Mitochondria-Targeting Peptide
A tetrapeptide that concentrates in the inner mitochondrial membrane and binds cardiolipin: stabilizes cristae, improves the electron transport chain, and lowers ROS.
Read guide →Epithalon: Telomeres, the Pineal Gland and Longevity
A pineal-derived bioregulator tetrapeptide (AEDG). Telomerase, melatonin rhythm, and longevity models — what the evidence shows and where it's preliminary.
Read guide →KPV: Anti-inflammatory Tripeptide for Skin & Mucosa
The α-MSH C-terminal fragment with potent anti-inflammatory activity in psoriasis, eczema, colitis, and wound healing models. Why it's in GLOW and KLOW.
Read guide →Thymosin Alpha-1: The Thymic Immunomodulating Peptide
A 28-amino-acid thymic peptide (thymalfasin / Zadaxin). Modulates T cells, NK cells and dendritic cells via TLRs. Evidence in chronic hepatitis, sepsis and oncology — one of the most studied immunomodulatory peptides.
Read guide →GHK-Cu: Copper-Tripeptide, Dermal Regenerator & Senescence
Pickart isolated it from human plasma in 1973. Regulates collagen, reverses senescence markers in fibroblasts, and is the regenerative anchor in GLOW and KLOW.
Read guide →GLOW vs KLOW: Which Repair Blend to Choose
BPC-157 + GHK-Cu + TB-500 (GLOW) vs the same + KPV (KLOW). What each component adds and when to choose each blend.
Read guide →CJC-1295 + Ipamorelin: The Most-Studied GH Stack
GHRH + ghrelin secretagogue. Why this combination produces an endogenous GH pulse superior to either alone — and how to dose the pre-mixed blend.
Read guide →Tesamorelin: GHRH Analog and Visceral Fat
A stabilized GHRH analog that stimulates pulsatile endogenous GH. Most studied for visceral and liver fat reduction. How it differs from exogenous GH and secretagogues.
Read guide →Fat Loss: Complete Peptide Guide (2026)
From GLP-1 agonists (Tirzepatide, Retatrutide) to adjuvants (5-Amino-1MQ, SLU-PP-332, AOD-9604, MOTS-c). The complete map of what each compound does and how they stack in research.
Read guide →Tirzepatide vs Retatrutide: Mechanism, Studies and Dose Differences
Technical comparison: FDA-approved GLP-1/GIP dual agonist vs Phase III triple agonist.
Read guide →Retatrutide: Triple GLP-1 / GIP / Glucagon Agonist
The first triple agonist in clinical research. Mechanism of all three receptors, Phase 2 results (NEJM 2023), the Phase 3 TRIUMPH program, and how it differs from tirzepatide and semaglutide.
Read guide →BPC-157: Mechanism, Published Studies and Recovery Applications
The most-studied gastric body peptide in animal models of tissue repair.
Read guide →Wolverine Stack: BPC-157 + TB-500 Recovery Synergy
Why BPC-157 + TB-500 is the most-studied combination in injury recovery research programs — and how to dose the pre-mixed 10 mg + 10 mg blend.
Read guide →Peptide Reconstitution: Complete Guide with Examples
How to reconstitute a lyophilized vial step-by-step, formulas, U100 units.
Read guide →GLP-1 Agonists: How Incretin Analogs Work
GLP-1, GIP, glucagon — biology behind Tirzepatide, Retatrutide, Semaglutide.
Read guide →DSIP: Delta Sleep-Inducing Peptide
A nonapeptide isolated in 1977 during delta-wave sleep. A neuromodulator of sleep and the stress axis — not a classic sedative. What the evidence says.
Read guide →Semax and Selank: The Russian Peptide Nootropics
Semax (BDNF/NGF, focus and neuroprotection) and Selank (anxiolytic without sedation, GABA/serotonin). What each does and when to research each peptide.
Read guide →Pinealon: A Peptide Bioregulator for Neuroprotection
A short tripeptide (EDR) from the Khavinson family. Neuroprotection, oxidative stress, and cognition in preclinical models. Its relationship to Epithalon.
Read guide →PT-141 (Bremelanotide): A Melanocortin Receptor Agonist
An α-MSH analog acting centrally at the MC4R receptor — a different mechanism from vascular agents. The melanocortin system and clinical context.
Read guide →TB-500: Thymosin Beta-4 Fragment
A synthetic fragment of Thymosin β4 that regulates actin and supports cell migration, angiogenesis, and flexibility. Why it is the other half of the Wolverine Stack.
Read guide →Tirzepatide: Dual GLP-1 / GIP Agonist
The first FDA-approved dual GIP/GLP-1 agonist: its dual mechanism, the SURPASS and SURMOUNT results, and how it differs from semaglutide and retatrutide.
Read guide →KLOW: The Repair Blend with KPV
BPC-157 + GHK-Cu + TB-500 + KPV in one vial. KPV is what sets KLOW apart from GLOW — what each component adds and how the 4-in-1 repair blend is dosed.
Read guide →Melanotan II: Melanocortin Agonist
A cyclic α-MSH analog that activates several melanocortin receptors — hence its two most studied effects: pigmentation (MC1R) and libido (MC4R). Includes reported research cautions.
Read guide →IGF-1 LR3: Long-Acting Analog
A long-acting IGF-1 analog: the Arg3 substitution and an N-terminal extension reduce IGFBP binding, multiplying its half-life and potency at the IGF-1R receptor.
Read guide →Oxytocin: The Bonding Neuropeptide
Nine amino acids with a dual role: classic reproductive hormone and neuromodulator of social bonding, trust, and stress. What is being researched and what is not established.
Read guide →Kisspeptin-10: The Switch of the Reproductive Axis
The master regulator of the reproductive axis: it activates GnRH neurons via the KISS1R receptor and, with them, the entire LH/FSH cascade that governs puberty and fertility.
Read guide →LL-37: The Human Antimicrobial Peptide
The only human cathelicidin: 37 amino acids forming the first line of innate defense, with additional roles in wound healing, angiogenesis and immunomodulation.
Read guide →GHRP-6: GH Secretagogue and Ghrelin
A GH-releasing hexapeptide that acts on the ghrelin receptor — and, with that, also triggers appetite. How it compares to ipamorelin and why it is combined with a GHRH.
Read guide →Cerebrolysin: Neurotrophic Peptide Blend
A blend of low-molecular-weight neuropeptides that mimics the activity of neurotrophic factors such as BDNF and GDNF. What the studies in stroke and dementia show.
Read guide →ARA-290 (Cibinetide): The Innate Repair Receptor
An 11-amino-acid peptide derived from the B helix of erythropoietin — without raising hematocrit. Activates the innate repair receptor to modulate inflammation and neuropathic pain.
Read guide →AOD-9604: hGH Fragment for Lipolysis
The 176-191 fragment of growth hormone: it retains the lipolytic action of hGH but not its effects on glucose or IGF-1. Mechanism, published studies and research context.
Read guide →5-Amino-1MQ: NNMT Inhibitor
Not a peptide but a small molecule that inhibits the NNMT enzyme, raising cellular NAD+ and reducing fat storage in the adipocyte in preclinical models.
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