Renova Guides
Knowledge base for peptide research. Mechanisms, published studies, reconstitution, stacks — curated by our team.
World Peptide Congress 2026: The Science Behind Renova
We follow the world's leading peptide educators and researchers — the SSRP Institute. The congress's core ideas, in a research frame, linked to our guides.
Read guide →Peptide Stacking: Synergy, Sequencing, and Combinations
Regenerative medicine is graduating from the single-site injection — but most stacking is still sequential, not combined. How to combine well, and the most-studied combinations.
Read guide →MOTS-c: The Mitochondrial Peptide Explained
Encoded in mitochondrial DNA, MOTS-c regulates metabolism, insulin sensitivity, and exercise response. Why it's become one of the most studied compounds in metabolic longevity research.
Read guide →NAD+: The Coenzyme of Cellular Energy and Longevity
The redox coenzyme that drops ~50% by midlife. Mitochondrial energy, DNA repair, sirtuins, and why it's central to longevity research.
Read guide →Glutathione: The Body's Master Antioxidant
The most abundant intracellular antioxidant tripeptide. GSH/GSSG redox cycle, hepatic detoxification, and why the injectable route is studied.
Read guide →SS-31 (Elamipretide): The Mitochondria-Targeting Peptide
A tetrapeptide that concentrates in the inner mitochondrial membrane and binds cardiolipin: stabilizes cristae, improves the electron transport chain, and lowers ROS.
Read guide →Epithalon: Telomeres, the Pineal Gland and Longevity
A pineal-derived bioregulator tetrapeptide (AEDG). Telomerase, melatonin rhythm, and longevity models — what the evidence shows and where it's preliminary.
Read guide →KPV: Anti-inflammatory Tripeptide for Skin & Mucosa
The α-MSH C-terminal fragment with potent anti-inflammatory activity in psoriasis, eczema, colitis, and wound healing models. Why it's in GLOW and KLOW.
Read guide →Thymosin Alpha-1: The Thymic Immunomodulating Peptide
A 28-amino-acid thymic peptide (thymalfasin / Zadaxin). Modulates T cells, NK cells and dendritic cells via TLRs. Evidence in chronic hepatitis, sepsis and oncology — one of the most studied immunomodulatory peptides.
Read guide →GHK-Cu: Copper-Tripeptide, Dermal Regenerator & Senescence
Pickart isolated it from human plasma in 1973. Regulates collagen, reverses senescence markers in fibroblasts, and is the regenerative anchor in GLOW and KLOW.
Read guide →GLOW vs KLOW: Which Repair Blend to Choose
BPC-157 + GHK-Cu + TB-500 (GLOW) vs the same + KPV (KLOW). What each component adds and when to choose each blend.
Read guide →CJC-1295 + Ipamorelin: The Most-Studied GH Stack
GHRH + ghrelin secretagogue. Why this combination produces an endogenous GH pulse superior to either alone — and how to dose the pre-mixed blend.
Read guide →Tesamorelin: GHRH Analog and Visceral Fat
A stabilized GHRH analog that stimulates pulsatile endogenous GH. Most studied for visceral and liver fat reduction. How it differs from exogenous GH and secretagogues.
Read guide →Fat Loss: Complete Peptide Guide (2026)
From GLP-1 agonists (Tirzepatide, Retatrutide) to adjuvants (5-Amino-1MQ, SLU-PP-332, AOD-9604, MOTS-c). The complete map of what each compound does and how they stack in research.
Read guide →Tirzepatide vs Retatrutide: Mechanism, Studies and Dose Differences
Technical comparison: FDA-approved GLP-1/GIP dual agonist vs Phase III triple agonist.
Read guide →Retatrutide: Triple GLP-1 / GIP / Glucagon Agonist
The first triple agonist in clinical research. Mechanism of all three receptors, Phase 2 results (NEJM 2023), the Phase 3 TRIUMPH program, and how it differs from tirzepatide and semaglutide.
Read guide →BPC-157: Mechanism, Published Studies and Recovery Applications
The most-studied gastric body peptide in animal models of tissue repair.
Read guide →Wolverine Stack: BPC-157 + TB-500 Recovery Synergy
Why BPC-157 + TB-500 is the most-studied combination in injury recovery research programs — and how to dose the pre-mixed 10 mg + 10 mg blend.
Read guide →Peptide Reconstitution: Complete Guide with Examples
How to reconstitute a lyophilized vial step-by-step, formulas, U100 units.
Read guide →GLP-1 Agonists: How Incretin Analogs Work
GLP-1, GIP, glucagon — biology behind Tirzepatide, Retatrutide, Semaglutide.
Read guide →DSIP: Delta Sleep-Inducing Peptide
A nonapeptide isolated in 1977 during delta-wave sleep. A neuromodulator of sleep and the stress axis — not a classic sedative. What the evidence says.
Read guide →Semax and Selank: The Russian Peptide Nootropics
Semax (BDNF/NGF, focus and neuroprotection) and Selank (anxiolytic without sedation, GABA/serotonin). What each does and when to research each peptide.
Read guide →Pinealon: A Peptide Bioregulator for Neuroprotection
A short tripeptide (EDR) from the Khavinson family. Neuroprotection, oxidative stress, and cognition in preclinical models. Its relationship to Epithalon.
Read guide →PT-141 (Bremelanotide): A Melanocortin Receptor Agonist
An α-MSH analog acting centrally at the MC4R receptor — a different mechanism from vascular agents. The melanocortin system and clinical context.
Read guide →TB-500: Thymosin Beta-4 Fragment
A synthetic fragment of Thymosin β4 that regulates actin and supports cell migration, angiogenesis, and flexibility. Why it is the other half of the Wolverine Stack.
Read guide →Tirzepatide: Dual GLP-1 / GIP Agonist
The first FDA-approved dual GIP/GLP-1 agonist: its dual mechanism, the SURPASS and SURMOUNT results, and how it differs from semaglutide and retatrutide.
Read guide →KLOW: The Repair Blend with KPV
BPC-157 + GHK-Cu + TB-500 + KPV in one vial. KPV is what sets KLOW apart from GLOW — what each component adds and how the 4-in-1 repair blend is dosed.
Read guide →Melanotan II: Melanocortin Agonist
A cyclic α-MSH analog that activates several melanocortin receptors — hence its two most studied effects: pigmentation (MC1R) and libido (MC4R). Includes reported research cautions.
Read guide →IGF-1 LR3: Long-Acting Analog
A long-acting IGF-1 analog: the Arg3 substitution and an N-terminal extension reduce IGFBP binding, multiplying its half-life and potency at the IGF-1R receptor.
Read guide →Oxytocin: The Bonding Neuropeptide
Nine amino acids with a dual role: classic reproductive hormone and neuromodulator of social bonding, trust, and stress. What is being researched and what is not established.
Read guide →Kisspeptin-10: The Switch of the Reproductive Axis
The master regulator of the reproductive axis: it activates GnRH neurons via the KISS1R receptor and, with them, the entire LH/FSH cascade that governs puberty and fertility.
Read guide →LL-37: The Human Antimicrobial Peptide
The only human cathelicidin: 37 amino acids forming the first line of innate defense, with additional roles in wound healing, angiogenesis and immunomodulation.
Read guide →GHRP-6: GH Secretagogue and Ghrelin
A GH-releasing hexapeptide that acts on the ghrelin receptor — and, with that, also triggers appetite. How it compares to ipamorelin and why it is combined with a GHRH.
Read guide →Cerebrolysin: Neurotrophic Peptide Blend
A blend of low-molecular-weight neuropeptides that mimics the activity of neurotrophic factors such as BDNF and GDNF. What the studies in stroke and dementia show.
Read guide →ARA-290 (Cibinetide): The Innate Repair Receptor
An 11-amino-acid peptide derived from the B helix of erythropoietin — without raising hematocrit. Activates the innate repair receptor to modulate inflammation and neuropathic pain.
Read guide →AOD-9604: hGH Fragment for Lipolysis
The 176-191 fragment of growth hormone: it retains the lipolytic action of hGH but not its effects on glucose or IGF-1. Mechanism, published studies and research context.
Read guide →5-Amino-1MQ: NNMT Inhibitor
Not a peptide but a small molecule that inhibits the NNMT enzyme, raising cellular NAD+ and reducing fat storage in the adipocyte in preclinical models.
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