Kisspeptin-10: The Switch of the Reproductive Axis
The master regulator of the reproductive axis: it activates GnRH neurons and, with them, the entire LH/FSH cascade that governs puberty and fertility.
What Kisspeptin-10 is
Kisspeptin-10 is a 10-amino-acid fragment of kisspeptin, the peptide encoded by the KISS1 gene. It is considered the master regulator of the onset of puberty and of reproductive function.
The GnRH axis
It acts on the KISS1R (GPR54) receptor on hypothalamic GnRH neurons. By activating them, it triggers the release of GnRH and, in cascade, of LH and FSH from the pituitary — which in turn regulate the gonads, testosterone and estrogens. Without kisspeptin signaling, the reproductive axis is not activated.
Research lines
Groups such as the one at Imperial College London have studied it as a diagnostic tool for hypothalamic function and in reproductive disorders (hypothalamic amenorrhea, infertility), for its ability to stimulate the axis in a physiological, pulsatile manner. Research evidence; RUO context, not medical advice.
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⚠ For research use only. Not medical advice.