KPV: Anti-inflammatory Tripeptide for Skin & Mucosa

What is KPV

KPV (Lys-Pro-Val) is a tripeptide from the α-MSH C-terminus. Unlike full α-MSH, KPV does not activate melanocortin receptors — no pigmentation. Retains anti-inflammatory activity.

Anti-inflammatory mechanism

• NF-κB suppression in keratinocytes and macrophages.
• TNF-α and IL-1β reduction.
• IL-10 modulation (anti-inflammatory).
• Topical penetration documented in murine models.

Key studies

Psoriasis (imiquimod model): topical KPV reduces erythema and epidermal thickness. DSS colitis: oral KPV reduces histological severity. Diabetic wound models: accelerated closure.

Routes of administration

SC (systemic), topical (cream/water on skin), oral (relatively resistant to gastric degradation). Range: 200 mcg – 1 mg/day.

Reconstitution

10 mg + 1 mL BAC = 10 mg/mL. 500 mcg dose = 0.05 mL = 5 units U100.

GLOW vs KLOW

GLOW = BPC + GHK-Cu + TB-500 (repair + ECM). KLOW = GLOW + KPV (adds anti-inflammatory). Use KLOW when inflammation is part of the picture (psoriasis, eczema, active dermatitis).

−15% promo

KPV 10mg is on continuous −15% promo alongside MOTS-c and ARA-290. View KPV.