MOTS-c: The Mitochondrial Peptide Explained

What is MOTS-c

MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA — discovered by Lee et al. (USC, 2015). Functions as a "mitochondrial signal" that travels to other tissues and modulates systemic metabolism.

Mechanism

• AMPK activation — cellular energy sensor.
• Folate/methionine modulation — interferes with AICAR/IMP.
• Insulin sensitivity — restores glucose uptake in skeletal muscle.
• BAT thermogenesis — increases energy expenditure in brown adipose.

Result in pre-clinical: "exercise mimic" at cellular level.

Published studies

Lee 2015 (Cell Metabolism): IP MOTS-c restored insulin sensitivity in HFD-fed mice. Reynolds 2021 (Nature Comm): improved endurance in middle-aged mice via mitochondrial gene expression.

Research dose ranges

Animal: 0.5–5 mg/kg SC/IP. Human research literature (self-reported): 5–15 mg/week divided in 2–3 doses SC. Descriptive context only.

Reconstitution

40 mg vial + 2 mL BAC = 20 mg/mL. 5 mg dose = 0.25 mL = 25 units U100.

Stacks

• NAD+ + Glutathione — full mitochondrial support.
• SS-31 — cardiolipin stabilization.
• Tirzepatide/Retatrutide — preserves lean mass during incretin-driven fat loss.

Why on promo −15%

MOTS-c 40mg is a best seller. May 2026 promo (−15%) reflects recent bulk purchase — auto-applied at cart. View MOTS-c.