TB-500: Thymosin Beta-4 Fragment
A synthetic fragment of Thymosin Ī²4 that regulates actin and supports cell migration, angiogenesis, and flexibility. Why it is the other half of the Wolverine Stack.
What TB-500 is
TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4 (TĪ²4), a natural 43-amino-acid protein present in nearly all tissues and in high concentrations in platelets and wound fluids.
Molecular mechanism
The central axis is its binding to G-actin, the main regulator of cytoskeleton assembly:
- Cell migration ā facilitates the movement of repair cells toward the injured area.
- Angiogenesis ā promotes the formation of new vessels that supply the tissue under repair.
- Inflammatory modulation ā reduces inflammatory markers in injury models.
Published studies
TĪ²4 has been investigated in animal models of repair of the cornea, skin, heart (post-infarction), and muscle-tendon tissue, with results associated with greater cell migration and revascularization. Most of the evidence is preclinical.
Stacks & dosing
The most studied combination is with BPC-157 ā the Wolverine Stack: BPC-157 acts locally and TB-500 systemically, covering complementary mechanisms. Reported research ranges involve loading phases and weekly SC maintenance; descriptive context, not a clinical recommendation.
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ā For research use only. Not medical advice.