Master Guide · Fat Loss

Fat Loss: Complete Peptide Guide (2026)

From GLP-1 agonists (Tirzepatide, Retatrutide) to adjuvants (5-Amino-1MQ, SLU-PP-332, AOD-9604, MOTS-c). The complete map of what each compound does and how they stack in research.

📖 9 min read 📅 Updated 2026-05-16

The complete map

Modern fat-loss peptide research operates in 4 layers:

Appetite/glycemia reduction — GLP-1, GIP, glucagon agonists.
Fat oxidation increase — thermogenesis, ERR, AMPK.
Specific lipolysis — HGH fragments, carnitine.
Lean mass preservation — MOTS-c, select GH peptides.

Layer 1: Incretins

Retatrutide (triple, Phase III, ~24% at 12mg) vs Tirzepatide (dual, FDA approved, ~20.9% at 15mg). See comparison.

Layer 2: Thermogenesis

SLU-PP-332: ERR agonist, "exercise mimic". 5-Amino-1MQ: NNMT inhibitor, elevates NAD+, preserves lean mass during fat loss.

Layer 3: Lipolysis

AOD-9604: HGH(176-191) fragment, lipolysis-only without anabolic or IGF-1 activity. SC, ~30 min half-life.

Layer 4: Preservation

MOTS-c: insulin sensitivity + mitochondria preservation during caloric restriction. See MOTS-c guide.

Sample advanced stack

Retatrutide 2 mg/week SC (titrate from 1mg).
MOTS-c 5 mg 2×/week SC.
AOD-9604 300 mcg/day SC morning fasted.
5-Amino-1MQ 50–100 mg/day oral.

Typical cycle: 12–16 weeks. Track via DEXA/BIA + metabolic panel + IGF-1.

Stack cost

Monthly estimate of advanced stack: Reta ($165) + MOTS-c ($228 promo) + AOD ($185) + 5-Amino-1MQ ($329) = ~$907/month. Simple version (Reta + MOTS-c): ~$393/month.