Fat Loss: Complete Peptide Guide (2026)
From GLP-1 agonists (Tirzepatide, Retatrutide) to adjuvants (5-Amino-1MQ, SLU-PP-332, AOD-9604, MOTS-c). The complete map of what each compound does and how they stack in research.
The complete map
Modern fat-loss peptide research operates in 4 layers:
- Appetite/glycemia reduction — GLP-1, GIP, glucagon agonists.
- Fat oxidation increase — thermogenesis, ERR, AMPK.
- Specific lipolysis — HGH fragments, carnitine.
- Lean mass preservation — MOTS-c, select GH peptides.
Layer 1: Incretins
Retatrutide (triple, Phase III, ~24% at 12mg) vs Tirzepatide (dual, FDA approved, ~20.9% at 15mg). See comparison.
Layer 2: Thermogenesis
SLU-PP-332: ERR agonist, "exercise mimic". 5-Amino-1MQ: NNMT inhibitor, elevates NAD+, preserves lean mass during fat loss.
Layer 3: Lipolysis
AOD-9604: HGH(176-191) fragment, lipolysis-only without anabolic or IGF-1 activity. SC, ~30 min half-life.
Layer 4: Preservation
MOTS-c: insulin sensitivity + mitochondria preservation during caloric restriction. See MOTS-c guide.
Sample advanced stack
- Retatrutide 2 mg/week SC (titrate from 1mg).
- MOTS-c 5 mg 2×/week SC.
- AOD-9604 300 mcg/day SC morning fasted.
- 5-Amino-1MQ 50–100 mg/day oral.
Typical cycle: 12–16 weeks. Track via DEXA/BIA + metabolic panel + IGF-1.
Stack cost
Monthly cost depends on the stack you choose and current prices. See the catalog for each compound’s current price.
Related products
⚠ Research use only. Not medical advice.